The existing answers just show how to achieve the effect of "compile-time assertions" based on the size of a type. That may meet the OP's needs in this particular case, but there are other cases where you really need a preprocessor conditional based on the size of a type. Here's how to do it:
Write yourself a little C program like:
/* you could call this sizeof_int.c if you like... */
#include <stdio.h>
/* 'int' is just an example, it could be any other type */
int main(void) { printf("%zd", sizeof(int); }
Compile that. Write a script in your favorite scripting language, which runs the above C program and captures its output. Use that output to generate a C header file. For example, if you were using Ruby, it might look like:
sizeof_int = `./sizeof_int`
File.open('include/sizes.h','w') { |f| f.write(<<HEADER) }
/* COMPUTER-GENERATED, DO NOT EDIT BY HAND! */
#define SIZEOF_INT #{sizeof_int}
/* others can go here... */
HEADER
Then add a rule to your Makefile or other build script, which will make it run the above script to build sizes.h.
Include sizes.h wherever you need to use preprocessor conditionals based on sizes.
Done!
(Have you ever typed ./configure && make to build a program? What configure scripts do is basically just like the above...)