Endonuclease, poly(u) specific

ENDOU
Identifiers
Aliases	ENDOU, P11, PP11, PRSS26, endonuclease, poly(U) specific
External IDs	OMIM: 606720; MGI: 97746; HomoloGene: 48394; GeneCards: ENDOU; OMA:ENDOU - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	47,725,567 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; oral cavity; ; epithelium of esophagus; ; mucosa of pharynx; ; human penis; ; body of tongue; ; skin of abdomen; ; vulva; ; skin of arm; ; skin of leg;
	Top expressed in
	thymus; ; esophagus; ; lip; ; skin of abdomen; ; skin of external ear; ; condyle; ; skin of back; ; hair follicle; ; medial dorsal nucleus; ; umbilical cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	manganese ion binding; polysaccharide binding; metal ion binding; scavenger receptor activity; RNA binding; nuclease activity; endonuclease activity; serine-type peptidase activity; growth factor activity; hydrolase activity; endoribonuclease activity;
Cellular component	cytoplasm; plasma membrane; extracellular region; extracellular space;
Biological process	nucleic acid phosphodiester bond hydrolysis; female pregnancy; receptor-mediated endocytosis; proteolysis; immune response; RNA phosphodiester bond hydrolysis, endonucleolytic; regulation of signaling receptor activity; vesicle-mediated transport; endocytosis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8909
	19011
	ENSG00000111405
	ENSMUSG00000022468
	P21128
	n/a
	NM_006025; NM_001172439; NM_001172440
	NM_001168693; NM_008902
	NP_001165910; NP_001165911; NP_006016
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Endonuclease, poly(U) specific is a protein that in humans is encoded by the ENDOU gene. ^[4]

Function

This gene encodes a protein with endoribonuclease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Endonuclease, poly(U) specific". Retrieved 2018-08-17.

Malard F, Dias K, Baudy M, Thore S, Vialet B, Barthélémy P, Fribourg F, Karginov FV, Campagne S (April 2025). "Molecular basis for the calcium-dependent activation of the ribonuclease EndoU". Nat. Commun. 16: 3110. doi:10.1038/s41467-025-58462-6. PMC 11961692.

Function

References

Further reading