MS15203

MS15203
Identifiers
	IUPAC name 5-(2-methylprop-2-enoylamino)benzene-1,3-dicarboxylic acid;
CAS Number	73912-52-4;
PubChem CID	773544;
ChemSpider	676193;
CompTox Dashboard (EPA)	DTXSID50995912 ;
Chemical and physical data
Formula	C12H11NO5
Molar mass	249.222 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=C)C(=O)NC1=CC(=CC(=C1)C(=O)O)C(=O)O;
	InChI InChI=1S/C12H11NO5/c1-6(2)10(14)13-9-4-7(11(15)16)3-8(5-9)12(17)18/h3-5H,1H2,2H3,(H,13,14)(H,15,16)(H,17,18); Key:NVOBVSWSDYFEMR-UHFFFAOYSA-N;

MS15203 (5-Methacrylamidoisophthalic acid) is an experimental drug which acts as a selective agonist for the neuropeptide receptor GPR171. In studies on mice it increases food intake and has analgesic effects, but shows sex-selective activity with greater effects in male mice than in female mice.^[1]^[2]^[3]

References

^ Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, et al. (May 2016). "Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake". Science Signaling. 9 (430): ra55. doi:10.1126/scisignal.aac8035. PMC 5150984. PMID 27245612.
^ Ram A, Edwards T, McCarty A, Afrose L, McDermott MV, Bobeck EN (2021). "GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice". Frontiers in Pain Research. 2 695396. Lausanne, Switzerland. doi:10.3389/fpain.2021.695396. PMC 8915562. PMID 35295419.
^ McDermott MV, Ram A, Mattoon MT, Haderlie EE, Raddatz MC, Thomason MK, et al. (March 2023). "A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice". Pharmacology, Biochemistry, and Behavior. 224 173543. doi:10.1016/j.pbb.2023.173543. PMC 11472835. PMID 36933620.

[1] Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, et al. (May 2016). "Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake". Science Signaling. 9 (430): ra55. doi:10.1126/scisignal.aac8035. PMC 5150984. PMID 27245612.

[2] Ram A, Edwards T, McCarty A, Afrose L, McDermott MV, Bobeck EN (2021). "GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice". Frontiers in Pain Research. 2 695396. Lausanne, Switzerland. doi:10.3389/fpain.2021.695396. PMC 8915562. PMID 35295419.

[3] McDermott MV, Ram A, Mattoon MT, Haderlie EE, Raddatz MC, Thomason MK, et al. (March 2023). "A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice". Pharmacology, Biochemistry, and Behavior. 224 173543. doi:10.1016/j.pbb.2023.173543. PMC 11472835. PMID 36933620.

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