misfold

English

Etymology

From mis- +‎ fold.

Pronunciation

  • IPA(key): (verb) /mɪsˈfoʊld/
  • Audio (Southern England):(file)
  • IPA(key): (noun) /ˈmɪsfoʊld/
  • Audio (Southern England):(file)
  • Rhymes: -əʊld

Verb

misfold (third-person singular simple present misfolds, present participle misfolding, simple past and past participle misfolded)

  1. (biochemistry, intransitive, of a protein or nucleic acid) To fold into an unusual or incorrect tertiary structure; misfolded proteins occur in various diseases, including amyloidoses and dementias, although the question of causation versus consequence is not yet definitively answered for dementias.
    • 2021 March 1, Anderson, K.N., Overcast, W.B., Brosch, J.R., Graner, B.D., Veronesi, M.C., “Prionopathies and Prionlike Protein Aberrations in Neurodegenerative Diseases”, in American Society of Neuroradiology, volume 11, number 2, →DOI, pages 127-148:
      The prionopathies are best known among the neurodegenerative diseases for their ability to misfold, self-propagate, and infect other organisms.

Noun

misfold (plural misfolds)

  1. An incorrect or abnormal folding.
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