normoproteinemia

From normo- +‎ protein +‎ -emia.

• (General American) IPA^(key): /ˌnɔɹmoʊˌpɹoʊtiːnˈiːmiə/

normoproteinemia (uncountable)

1. (biology, medicine) Presence of a normal amount of protein in the blood.

   Antonyms: dysproteinemia; hypoproteinemia, hyperproteinemia

   Coordinate term: proteinemia (often antonymous)

   1. (usually) Total serum protein quantity within reference range.
      • 1960, Ferdinand Wuhrmann, Charlie Wunderly, The Human Blood Proteins: Methods of Examination and Their Clinical and Practical Significance‎^[1], Grune and Stratton, page 332:

        Under clinical conditions shifts among the fraction associated with total protein values within the normal range of 6.5—7.9 per cent are most frequently encountered, that is associated with normoproteinemia (see figure 96, page 338). Hyperproteinemia associated with obvious increase of the blood proteins is relatively rarely seen in clinical medicine, while serum protein diminution or hypoproteinemia is much more frequently found.

      • 2004, Edward C. Feldman, Richard William Nelson, “Hypercalcemia and primary hyperparathyroidism”, in Canine and Feline Endocrinology and Reproduction‎^[2], Elsevier, →ISBN, page 695:

        One of our dogs with PHPTH [primary hyperparathyroidism] had lucent lesions in the long bones, but this is extremely uncommon. Concurrent hyperproteinemia is supportive of myeloma. Solid tumors with metastasis to bone are more likely if lytic bone lesions and normoproteinemia (especially a normal serum globulin concentration) are present. A core biopsy of a lytic lesion may be necessary to establish a definitive diagnosis of neoplasia, especially in a dog with occult neoplasia.

      • 2008, Jiro Jerry Kaneko, John W. Harvey, Michael L. Bruss, “Interpretation of serum protein profiles”, in Clinical Biochemistry of Domestic Animals‎^[3], Academic Press, →ISBN, page 145:

        Decreased albumin is a common form of dysproteinemia. Fundamentally, the decrease can be attributed to either albumin loss or failure of albumin synthesis. Depending on the stage of the disease, it can be associated with either slight hyperproteinemia (acute stage), normoproteinemia (progressive stage), or, in its advanced stages, hypoproteinemia. Therefore, the total serum protein is not a reliable index of albumin status and albumin must be determined.

   2. (uncommon) Presence of normal types and amounts of proteins in the blood, as defined by panels of various proteins all having been tested and found to be of normal bioactivity and amount.