smoothened

English

Etymology 1

From smoothen +‎ -ed.

Verb

smoothened

  1. simple past and past participle of smoothen

Etymology 2

Ultimately the same as etymology 1. The gene encoding the protein was first identified in Drosophila melanogaster as a segment polarity gene and initially named smooth (smo) by Christiane Nüsslein-Volhard et al. in 1984.[1] This was later revised to smoothened by Dan L. Lindsley and Georgianna G. Zimm in 1992,[2] because the former name already described another locus.[3]

Alternative forms

  • Smoothened

Noun

smoothened (uncountable)

  2. (biochemistry) A transmembrane protein belonging to the group of G protein-coupled receptors that is a key component of the hedgehog signaling pathway.
    Synonym: (abbreviation) Smo
See also

References

  1. ^ Christiane Nüsslein-Volhard, Eric F. Wieschaus, H. Kluding (September 1984) “Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster: I. Zygotic loci on the second chromosome”, in Roux's Archives of Developmental Biology, volume 193, Springer-Verlag, →DOI, page 274
  2. ^ Dan L. Lindsley, Georgianna G. Zimm (1992) “Genes”, in The Genome of Drosophila melanogaster, San Diego, Calif.: Academic Press, Inc., →DOI, →ISBN, page 649
  3. ^ Joy Alcedo, Marina Ayzenzon, Tonia Von Ohlen, Markus Noll, Joan E. Hooper (26 July 1996) “The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal”, in Cell, volume 86, Cell Press, →DOI, pages 221–222
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