warfarin

English

Etymology

From Wisconsin Alumni Research Foundation +‎ (coum)arin.

Pronunciation

Noun

warfarin (countable and uncountable, plural warfarins)

  1. (pharmacology) A coumarin salt, warfarin sodium, found in certain clovers, that retards blood coagulation:
    • 2015 July 29, Carville G. Bevans et al., “Phylogeny of the Vitamin K 2,3-Epoxide Reductase (VKOR) Family and Evolutionary Relationship to the Disulfide Bond Formation Protein B (DsbB) Family”, in Nutrients‎[1], volume 7, →DOI:
      In the case of pathological hypercoagulative conditions such as thrombosis and embolism, 4-hydroxycoumarin based oral anticoagulants, including warfarin as a well-known example, are administered to block the enzymatic function of VKORC1, effectively diminishing turnover of the vitamin K cycle.
    1. Manufactured as a pharmaceutical drug and used in low dosage, with regular monitoring, for the prevention of thrombosis and embolism.
    2. Manufactured as a chemical, used in high dosage as a pesticide.

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