You can speed it up by using ByteStrings, e.g.
module Main (main) where
import System.Environment (getArgs)
import qualified Data.ByteString.Lazy.Char8 as C
import Data.Char
main :: IO ()
main = do
    args <- getArgs
    mapM_ doFile args
doFile :: FilePath -> IO ()
doFile file = do
    bs <- C.readFile file
    let tups = buildTups 0 [] $ C.dropWhile (not . isDigit) bs
    print (length tups)
buildTups :: Int -> [Int] -> C.ByteString -> [(Int,Int,Int,Int,Int,Int)]
buildTups 6 acc bs = tuplify6 acc : buildTups 0 [] bs
buildTups k acc bs
    | C.null bs = if k == 0 then [] else error ("Bad file format " ++ show k)
    | otherwise = case C.readInt bs of
                    Just (i,rm) -> buildTups (k+1) (i:acc) $ C.dropWhile (not . isDigit) rm
                    Nothing -> error ("No Int found: " ++ show (C.take 100 bs))
tuplify6:: [a] -> (a, a, a, a, a, a)
tuplify6 [l, m, n, o, p, q] = (l, m, n, o, p, q)
runs pretty fast:
$ time ./fileParse IntList 
200000
real    0m0.119s
user    0m0.115s
sys     0m0.003s
for an 8.1 MiB file.
On the other hand, using Strings and your conversion (with a couple of seqs to force evaluation) also took only 0.66s, so the bulk of the time seems to be spent not parsing, but working with the result.
Oops, missed a seq so the reads were not actually evaluated for the String version. Fixing that, String + read takes about four seconds, a bit above one with the custom Int parser from @Rotsor's comment
foldl' (\a c -> 10*a + fromEnum c - fromEnum '0') 0
so parsing apparently did take a significant amount of the time.