Using autofac as my IoC framework.
I'd like to be able to set up my DbContext instance in my application's startup.  
In my ASP.NET MVC 3 project, I register DbContext instance in Global.asax  (PerLifetimeScope). But when I fire up my site on multiple browsers (or multiple tabs) at once, sometimes I get Object reference not set to an instance of an object. or New transaction is not allowed because there are other threads running in the session when I try to save changes back to database. Also I get
ExecuteReader requires an open and available Connection. The connection's current state: Broken. sometimes when I want to read data from database.
the errors seem to pop up randomly and I suspect it has something to do with my context's lifetime scope. here's my DbContext's overriden SaveChange method.  
public class MyContext : DbContext
{ 
    public override int SaveChanges()
    {
        var result = base.SaveChanges(); // Exception here
    }
}
Here's how I register my context:
builder.Register(c => new MyContext("SomeConnectionString"))
                 .InstancePerLifetimeScope(); 
If I just have one open tab of my site in the browser everything works ok.
Also, It's worth mentioning I have CRUD operations with db every 5-10 seconds in my website by calling a controller method using Ajax.  
StackTrace for New transaction is not allowed because there are other threads running in the session:
at System.Data.EntityClient.EntityConnection.BeginDbTransaction(IsolationLevel isolationLevel)
at System.Data.EntityClient.EntityConnection.BeginTransaction()
at System.Data.Objects.ObjectContext.SaveChanges(SaveOptions options)
at System.Data.Entity.Internal.InternalContext.SaveChanges()
at System.Data.Entity.Internal.LazyInternalContext.SaveChanges()
at System.Data.Entity.DbContext.SaveChanges()
at MyProject.Data.MyContext.SaveChanges() in D:\Test.cs
StackTrace for Object reference not set to an instance of an object.:  
at System.Data.Objects.ObjectStateManager.DetectConflicts(IList`1 entries)
at System.Data.Objects.ObjectStateManager.DetectChanges()
at System.Data.Entity.Internal.InternalContext.DetectChanges(Boolean force)
at System.Data.Entity.Internal.InternalContext.GetStateEntries(Func`2 predicate)
at System.Data.Entity.Internal.InternalContext.GetStateEntries()
at System.Data.Entity.Infrastructure.DbChangeTracker.Entries()
at System.Data.Entity.DbContext.GetValidationErrors()
at System.Data.Entity.Internal.InternalContext.SaveChanges()
at System.Data.Entity.Internal.LazyInternalContext.SaveChanges()
at System.Data.Entity.DbContext.SaveChanges()
at MyProject.Data.MyContext.SaveChanges() in D:\Test.cs   at