This is a bit puzzling here. The following code is part of a little testing application to verify that code changes didn't introduce a regression. To make it fast we used memcmp which appears to be the fastest way of comparing two images of equal size (unsurprisingly).
However, we have a few test images that exhibit a rather surprising problem: memcmp on the bitmap data tells us that they are not equal, however, a pixel-by-pixel comparison doesn't find any difference at all. I was under the impression that when using LockBits on a Bitmap you get the actual raw bytes of the image. For a 24 bpp bitmap it's a bit hard to imagine a condition where the pixels are the same but the underlying pixel data isn't.
A few surprising things:
- The differences are always single bytes that are 
00in one image andFFin the other. - If one changes the 
PixelFormatforLockBitstoFormat32bppRgborFormat32bppArgb, the comparison succeeds. - If one passes the 
BitmapDatareturned by the firstLockBitscall as 4th argument to the second one, the comparison succeeds. - As noted above, the pixel-by-pixel comparison succeeds as well.
 
I'm a bit stumped here because frankly I cannot imagine why this happens.
(Reduced) Code below. Just compile with csc /unsafe and pass a 24bpp PNG image as first argument.
using System;
using System.Drawing;
using System.Drawing.Imaging;
using System.Runtime.InteropServices;
class Program
{
    public static void Main(string[] args)
    {
        Bitmap title = new Bitmap(args[0]);
        Console.WriteLine(CompareImageResult(title, new Bitmap(title)));
    }
    private static string CompareImageResult(Bitmap bmp, Bitmap expected)
    {
        string retval = "";
        unsafe
        {
            var rect = new Rectangle(0, 0, bmp.Width, bmp.Height);
            var resultData = bmp.LockBits(rect, ImageLockMode.ReadOnly, bmp.PixelFormat);
            var expectedData = expected.LockBits(rect, ImageLockMode.ReadOnly, expected.PixelFormat);
            try
            {
                if (memcmp(resultData.Scan0, expectedData.Scan0, resultData.Stride * resultData.Height) != 0)
                    retval += "Bitmap data did not match\n";
            }
            finally
            {
                bmp.UnlockBits(resultData);
                expected.UnlockBits(expectedData);
            }
        }
        for (var x = 0; x < bmp.Width; x++)
            for (var y = 0; y < bmp.Height; y++)
                if (bmp.GetPixel(x, y) != expected.GetPixel(x, y))
                {
                    Console.WriteLine("Pixel diff at {0}, {1}: {2} - {3}", x, y, bmp.GetPixel(x, y), expected.GetPixel(x, y));
                    retval += "pixel fail";
                }
        return retval != "" ? retval : "success";
    }
    [DllImport("msvcrt.dll", CallingConvention = CallingConvention.Cdecl)]
    static extern int memcmp(IntPtr b1, IntPtr b2, long count);
}