It may be concluded from answers here that NOT IN (subquery) doesn't handle nulls correctly and should be avoided in favour of NOT EXISTS. However, such a conclusion may be premature. In the following scenario, credited to Chris Date (Database Programming and Design, Vol 2 No 9, September 1989), it is NOT IN that handles nulls correctly and returns the correct result, rather than NOT EXISTS.
Consider a table sp to represent suppliers (sno) who are known to supply parts (pno) in quantity (qty). The table currently holds the following values:
      VALUES ('S1', 'P1', NULL), 
             ('S2', 'P1', 200),
             ('S3', 'P1', 1000)
Note that quantity is nullable i.e. to be able to record the fact a supplier is known to supply parts even if it is not known in what quantity. 
The task is to find the suppliers who are known supply part number 'P1' but not in quantities of 1000.
The following uses NOT IN to correctly identify supplier 'S2' only:
WITH sp AS 
     ( SELECT * 
         FROM ( VALUES ( 'S1', 'P1', NULL ), 
                       ( 'S2', 'P1', 200 ),
                       ( 'S3', 'P1', 1000 ) )
              AS T ( sno, pno, qty )
     )
SELECT DISTINCT spx.sno
  FROM sp spx
 WHERE spx.pno = 'P1'
       AND 1000 NOT IN (
                        SELECT spy.qty
                          FROM sp spy
                         WHERE spy.sno = spx.sno
                               AND spy.pno = 'P1'
                       );
However, the below query uses the same general structure but with NOT EXISTS but incorrectly includes supplier 'S1' in the result (i.e. for which the quantity is null):
WITH sp AS 
     ( SELECT * 
         FROM ( VALUES ( 'S1', 'P1', NULL ), 
                       ( 'S2', 'P1', 200 ),
                       ( 'S3', 'P1', 1000 ) )
              AS T ( sno, pno, qty )
     )
SELECT DISTINCT spx.sno
  FROM sp spx
 WHERE spx.pno = 'P1'
       AND NOT EXISTS (
                       SELECT *
                         FROM sp spy
                        WHERE spy.sno = spx.sno
                              AND spy.pno = 'P1'
                              AND spy.qty = 1000
                      );
So NOT EXISTS is not the silver bullet it may have appeared!
Of course, source of the problem is the presence of nulls, therefore the 'real' solution is to eliminate those nulls.
This can be achieved (among other possible designs) using two tables:
- spsuppliers known to supply parts
- spqsuppliers known to supply parts in known quantities
noting there should probably be a foreign key constraint where spq references sp.
The result can then be obtained using the 'minus' relational operator (being the EXCEPT keyword in Standard SQL) e.g. 
WITH sp AS 
     ( SELECT * 
         FROM ( VALUES ( 'S1', 'P1' ), 
                       ( 'S2', 'P1' ),
                       ( 'S3', 'P1' ) )
              AS T ( sno, pno )
     ),
     spq AS 
     ( SELECT * 
         FROM ( VALUES ( 'S2', 'P1', 200 ),
                       ( 'S3', 'P1', 1000 ) )
              AS T ( sno, pno, qty )
     )
SELECT sno
  FROM spq
 WHERE pno = 'P1'
EXCEPT 
SELECT sno
  FROM spq
 WHERE pno = 'P1'
       AND qty = 1000;