If you are doing complex, async input validation it might be worth it to abstract ng-model up one level as part of a custom class with its own validation methods.
https://plnkr.co/edit/gUnUjs0qHQwkq2vPZlpO?p=preview
html
<div>
  <label for="a">input a</label>
  <input 
    ng-class="{'is-valid': vm.store.a.isValid == true, 'is-invalid': vm.store.a.isValid == false}"
    ng-keyup="vm.store.a.validate(['isEmpty'])"
    ng-model="vm.store.a.model"
    placeholder="{{vm.store.a.isValid === false ? vm.store.a.warning : ''}}"
    id="a" />
  <label for="b">input b</label>
  <input 
    ng-class="{'is-valid': vm.store.b.isValid == true, 'is-invalid': vm.store.b.isValid == false}"
    ng-keyup="vm.store.b.validate(['isEmpty'])"
    ng-model="vm.store.b.model"
    placeholder="{{vm.store.b.isValid === false ? vm.store.b.warning : ''}}"
    id="b" />
</div>
code
(function() {
  const _ = window._;
  angular
    .module('app', [])
    .directive('componentLayout', layout)
    .controller('Layout', ['Validator', Layout])
    .factory('Validator', function() { return Validator; });
  /** Layout controller */
  function Layout(Validator) {
    this.store = {
      a: new Validator({title: 'input a'}),
      b: new Validator({title: 'input b'})
    };
  }
  /** layout directive */
  function layout() {
    return {
      restrict: 'EA',
      templateUrl: 'layout.html',
      controller: 'Layout',
      controllerAs: 'vm',
      bindToController: true
    };
  }
  /** Validator factory */  
  function Validator(config) {
    this.model = null;
    this.isValid = null;
    this.title = config.title;
  }
  Validator.prototype.isEmpty = function(checkName) {
    return new Promise((resolve, reject) => {
      if (/^\s+$/.test(this.model) || this.model.length === 0) {
        this.isValid = false;
        this.warning = `${this.title} cannot be empty`;
        reject(_.merge(this, {test: checkName}));
      }
      else {
        this.isValid = true;
        resolve(_.merge(this, {test: checkName}));
      }
    });
  };
  /**
   * @memberof Validator
   * @param {array} checks - array of strings, must match defined Validator class methods
   */
  Validator.prototype.validate = function(checks) {
    Promise
      .all(checks.map(check => this[check](check)))
      .then(res => { console.log('pass', res)  })
      .catch(e => { console.log('fail', e) })
  };
})();