I needed this in a Dictionary<Tuple<>> wrapper, so I used @Jon 's code to create a generic version 
public class TupleEqualityComparer<T1, T2> : IEqualityComparer<Tuple<T1, T2>>
{
    private IEqualityComparer<T1> comparer1;
    private IEqualityComparer<T2> comparer2;
    public TupleEqualityComparer(IEqualityComparer<T1> comparer1, IEqualityComparer<T2> comparer2)
    {
        this.comparer1 = comparer1 ?? EqualityComparer<T1>.Default;
        this.comparer2 = comparer2 ?? EqualityComparer<T2>.Default;
    }
    public bool Equals(Tuple<T1, T2> lhs, Tuple<T1, T2> rhs)
    {
        return comparer1.Equals(lhs.Item1, rhs.Item1) && comparer2.Equals(lhs.Item2, rhs.Item2);
    }
    public int GetHashCode(Tuple<T1, T2> tuple)
    {
        return comparer1.GetHashCode(tuple.Item1) ^ comparer2.GetHashCode(tuple.Item2);
    }
}
public class Dictionary<TKey1, TKey2, TValue> : Dictionary<Tuple<TKey1, TKey2>, TValue>()
{
    public Dictionary() : base() { }
    public Dictionary(IEqualityComparer<TKey1> comparer1, IEqualityComparer<TKey2> comparer2) : base(new TupleEqualityComparer<TKey1, Tkey2>(comparer1, comparer2) { }
    public TValue this[TKey1 key1, TKey2 key2]
    {
        get { return base[Tuple.Create(key1, key2)]; }
    }
    public void Add(TKey1 key1, TKey2 key2, TValue value)
    {
        base.Add(Tuple.Create(key1, key2), value);
    }
    public bool ContainsKey(TKey1 key1, TKey2 key2)
    {
        return base.ContainsKey(Tuple.Create(key1, key2));
    }
    public bool TryGetValue(TKey1 key1, TKey2 key2, out TValue value)
    {
        return base.TryGetValue(Tuple.Create(key1, key2), out value);
    }
}
Usage
var dict = new Dictionary<string, DateTime, int>(
    StringComparer.OrdinalIgnoreCase, null);
dict.Add("value1", DateTime.Now, 123);
Assert.IsTrue(dict.ContainsKey("VALUe1"));