My ServiceStack web service works fine in IIS Express (VS 2012) and when deployed to Windows Azure, but it does not work under IIS 8 on Window 8.
I am getting 404 Not Found Error.  My web.config has both sections defined for IIS Express and the web server. 
<?xml version="1.0" encoding="UTF-8"?>
<configuration>
   <system.web>
    <compilation debug="true" targetFramework="4.5">
      <assemblies>
        <add assembly="System.Web.WebPages.Razor, Version=1.0.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" />
      </assemblies>
      <buildProviders>
        <add extension=".cshtml" type="ServiceStack.Razor.CSharpRazorBuildProvider, ServiceStack.Razor" />
      </buildProviders>
    </compilation>
    <httpRuntime targetFramework="4.5" />
  </system.web>
  <system.webServer>
    <validation validateIntegratedModeConfiguration="false" />
    <handlers>
      <add path="*" name="ServiceStack.Factory" type="ServiceStack.WebHost.Endpoints.ServiceStackHttpHandlerFactory, ServiceStack" verb="*" preCondition="integratedMode" resourceType="Unspecified" allowPathInfo="true" />
    </handlers>
  </system.webServer>
</configuration>
Solution:
Just figured out, through further research, that this resolved my problem:
- I switched the application pool to Integrated Mode.
 I added the following to
web.config:<system.webServer> <modules runAllManagedModulesForAllRequests="true"/> </system.webServer>