I guess the pythonic way is to let different extensions interact via a C API. Although I am not very experienced with c++ I guess it is not so much different from the solution in C. I would do it the following way: 
- define the global variable in module A
 
- define a C API for module A, which contains a pointer to the global variable (and a macro for convenience if you wish).
 
- load the C API in module B and access the global variable via the pointer. 
 
Writing C APIs for python C extensions is a bit involved. (Read python docs on Python C API, if your are not familiar with it.)
The minimal example of my proposed solution would look like this:
A.h
/* Header file for A module */
#ifndef A_MODULE_H
#define A_MODULE_H
#ifdef __cplusplus
extern "C" {
#endif
#define PyA_GET_X() (*x_ptr)
#define PyA_SET_X(x) (*x_ptr = x)
#ifdef A_MODULE
/* do nothing for this minimal example */
#else
static void **PyA_API;
#define x_ptr ((long *)PyA_API[0])
static int import_A(void)
{
    PyA_API = (void **)PyCapsule_Import("A._C_API", 0);
    return (PyA_API != NULL) ? 0 : -1;
}
#endif /* !defined(A_MODULE) */
#ifdef __cplusplus
}
#endif
#endif /* !defined(A_MODULE_H) */
A.c
#include <Python.h>
#define A_MODULE
#include "A.h"
long x = 0; /* here is the global variable */
static PyObject* 
set_x(PyObject *self, PyObject *args){
    if (!PyArg_ParseTuple(args, "l", &x)) return NULL;
    Py_RETURN_NONE;
}
static PyObject* 
get_x(PyObject *self, PyObject *args){
    return PyInt_FromLong(x);
}
static PyMethodDef methods[] = {
    {"set_x", (PyCFunction)set_x, METH_VARARGS, ""},
    {"get_x", (PyCFunction)get_x, METH_NOARGS, ""},
    {NULL, NULL, 0, NULL}
    };
#ifndef PyMODINIT_FUNC  /* declarations for DLL import/export */
#define PyMODINIT_FUNC void
#endif
PyMODINIT_FUNC initA(void){
    PyObject *m = Py_InitModule3("A", methods, "");
    static void *PyA_API[1];
    PyA_API[0] = (void *)&x;
    PyObject *c_api_object = PyCapsule_New((void *)PyA_API, "A._C_API", NULL);
    if (c_api_object != NULL) PyModule_AddObject(m, "_C_API", c_api_object);
}
B.c
#include <Python.h>
#define B_MODULE
#include "A.h"
static PyObject* 
set_x(PyObject *self, PyObject *args){
    long y;
    if (!PyArg_ParseTuple(args, "l", &y)) return NULL;
    PyA_SET_X(y);
    Py_RETURN_NONE;
}
static PyObject* 
get_x(PyObject *self, PyObject *args){
    return PyInt_FromLong(PyA_GET_X());
}
static PyMethodDef methods[] = {
    {"set_x", (PyCFunction)set_x, METH_VARARGS, ""},
    {"get_x", (PyCFunction)get_x, METH_NOARGS, ""},
    {NULL, NULL, 0, NULL}
    };
#ifndef PyMODINIT_FUNC  /* declarations for DLL import/export */
#define PyMODINIT_FUNC void
#endif
PyMODINIT_FUNC initB(void){
    import_A();
    Py_InitModule3("B", methods, "");
}
setup.py
from numpy.distutils.core import setup, Extension
setup(
    name="AB",
    ext_modules = [Extension('A', ['A.c']), Extension('B', ['B.c'])],
    )
and finally you will be able to read and modify x from both modules, either from C level or python. In python this will look like:
>>> import A, B
>>> A.set_x(1)
>>> B.get_x()
    1
>>> B.set_x(2)
>>> A.get_x()
    2
for access from C level use macros PyA_GET_X() and PyA_SET_X(x).