For what you have described, You do not need to allocate memory for your struct, rather, you need to allocate memory for the members char *addr;, and char *inst;. If you want to have a single copy of that structure, the first section of code illustrates how to initialize, and assign values.  If you want an array, the second code example illustrates the differences.
This illustrates how to allocate memory for the members of a single struct line:
typedef struct
{
    char* addr;
    char* inst;
}LINE;
LINE line;  
int main(void)
{   
    strcpy(line.addr, "anystring"); //will fail
    line.addr = malloc(80);
    line.inst = malloc(80);
    strcpy(line.addr, "someString");//success;
    strcpy(line.inst, "someOtherString");//success;
}
For array of struct line...
typedef struct
{
    char* addr;
    char* inst;
}LINE;  //same struct definition
LINE line[10]; //but create an array of line here.
int main(void)
{   
    int i;
    
    for(i=0;i<10;i++)
    {
      line[i].addr = malloc(80);
      line[i].inst = malloc(80);
    }
    for(i=0;i<10;i++)
    {
        strcpy(line[i].addr, "someString");
        strcpy(line[i].inst, "someOtherString");
    }
    //when done, free memory
    for(i=0;i<10;i++)
    {
        free(line[i].addr);
        free(line[i].inst);
    }      
}
Added to address comment
Addressing the comment under this answer from @Adam Liss, the following code illustrates the following improvements using strdup(): 1) Uses only memory needed.  2) Performs memory creation and copy operations in one step, so the the following blocks:
for(i=0;i<10;i++)
{
  line[i].addr = malloc(80);
  line[i].inst = malloc(80);
}
for(i=0;i<10;i++)
{
    strcpy(line[i].addr, "someString");
    strcpy(line[i].inst, "someOtherString");
}
Become:
for(i=0;i<10;i++)
{
  line[i].addr = strdup("someString");
  line[i].inst = strdup("someOtherString");
}
One more note: Error handling was not included in examples above to avoid muddling up focus on the main concepts:  But for the sake of completeness, because both malloc() and strdup() can fail, actual usage for each of these two functions, should include a test before using, eg:
Rather than
  line[i].addr = strdup("someString");
  line[i].inst = strdup("someOtherString");
The code should include
  line[i].addr = strdup("someString");
  if(!line[i].addr)
  {
      //error handling code here
  }
  line[i].inst = strdup("someOtherString");
  if(!line[i].inst)
  {
      //error handling code here
  }