Beware of spending a lot of time thinking about optimization details which the compiler will just take care of for you.
Here are four implementations of what I understand the OP to be, along with the code generated using gcc 4.8 with --std=c++11 -O3 -S
Declarations:
#include <algorithm>
#include <vector>
struct T {
  int irrelevant;
  int relevant;
  double trailing;
};
Explicit loop implementations, roughly from answers and comments provided to OP. Both produced identical machine code, aside from labels.
                                                        .cfi_startproc
                                                        movq    (%rdi), %rsi
void clear_relevant(std::vector<T>* vecp) {             movq    8(%rdi), %rcx
  for(unsigned i=0; i<vecp->size(); i++) {              xorl    %edx, %edx
    vecp->at(i).relevant = 0;                           xorl    %eax, %eax
  }                                                     subq    %rsi, %rcx
}                                                       sarq    $4, %rcx
                                                        testq   %rcx, %rcx
                                                        je      .L1
                                                        .p2align 4,,10
                                                        .p2align 3
                                                .L5:
void clear_relevant2(std::vector<T>* vecp) {            salq    $4, %rdx
  std::vector<T>& vec = *vecp;                          addl    $1, %eax
  auto s = vec.size();                                  movl    $0, 4(%rsi,%rdx)
  for (unsigned i = 0; i < s; ++i) {                    movl    %eax, %edx
    vec[i].relevant = 0;                                cmpq    %rcx, %rdx
  }                                                     jb      .L5
}                                               .L1:
                                                        rep ret
                                                        .cfi_endproc
Two other versions, one using std::for_each and the other one using the range for syntax. Here there is a subtle difference in the code for the two versions (other than the labels):
                                                        .cfi_startproc
                                                        movq    8(%rdi), %rdx
                                                        movq    (%rdi), %rax
                                                        cmpq    %rax, %rdx
                                                        je      .L17
void clear_relevant3(std::vector<T>* vecp) {            .p2align 4,,10
  for (auto& p : *vecp) p.relevant = 0;                 .p2align 3
}                                               .L21:
                                                        movl    $0, 4(%rax)
                                                        addq    $16, %rax
                                                        cmpq    %rax, %rdx
                                                        jne     .L21
                                                .L17:
                                                        rep ret
                                                        .cfi_endproc
                                                        .cfi_startproc
                                                        movq    8(%rdi), %rdx
                                                        movq    (%rdi), %rax
                                                        cmpq    %rdx, %rax
void clear_relevant4(std::vector<T>* vecp) {            je      .L12
  std::for_each(vecp->begin(), vecp->end(),             .p2align 4,,10
                [](T& o){o.relevant=0;});               .p2align 3
}                                               .L16:
                                                        movl    $0, 4(%rax)
                                                        addq    $16, %rax
                                                        cmpq    %rax, %rdx
                                                        jne     .L16
                                                .L12:
                                                        rep ret
                                                        .cfi_endproc