Building it up piece by piece (and throughout assuming no newlines in the string or PATTERN):
This matches any string:
/^.*$/
But we don't want . to match a character that starts PATTERN, so replace
.
with
(?!PATTERN).
This uses a negative look-ahead that tests a given pattern without actually consuming any of the string and only succeeds if the pattern does not match at the given point in the string. So it's like saying:
if PATTERN doesn't match at this point,
match the next character
This needs to be done for every character in the string, so * is used to match zero or more times, from the beginning to the end of the string.
To make the * apply to the combination of the negative look-ahead and ., not just the ., it needs to be surrounded by parentheses, and since there's no reason to capture, they should be non-capturing parentheses (?: ):
(?:(?!PATTERN).)*
And putting back the anchors to make sure we test at every position in the string:
/^(?:(?!PATTERN).)*$/
Note that this solution is particularly useful as part of a larger match; e.g. to match any string with foo and later baz but no bar in between:
/foo(?:(?!bar).)*baz/
If there aren't such considerations, you can simply do:
/^(?!.*PATTERN)/
to check that PATTERN does not match anywhere in the string.
About newlines: there are two problems with your regex and newlines. First, . doesn't match newlines, so "foo\nbar" =~ /^(?:(?!baz).)*$/ doesn't match, even though the string does not contain baz. You need to add the /s flag to make . match any character; "foo\nbar" =~ /^(?:(?!baz).)*$/s correctly matches. Second, $ doesn't match just at the end of the string, it also can match before a newline at the end of the string. So "foo\n" =~ /^(?:(?!\s).)*$/s does match, even though the string contains whitespace and you are attempting to only match strings with no whitespace; \z always only matches at the end, so "foo\n" =~ /^(?:(?!\s).)*\z/s correctly fails to match the string that does in fact contain a \s. So the correct general purpose regex is:
/^(?:(?!PATTERN).)*\z/s