A comment on my answer to this question which should give the desired result using strsplit does not, even though it seems to correctly match the first and last commas in a character vector. This can be proved using gregexpr and regmatches.
So why does strsplit split on each comma in this example, even though regmatches only returns two matches for the same regex?
# We would like to split on the first comma and
# the last comma (positions 4 and 13 in this string)
x <- "123,34,56,78,90"
# Splits on every comma. Must be wrong.
strsplit( x , '^\\w+\\K,|,(?=\\w+$)' , perl = TRUE )[[1]]
#[1] "123" "34" "56" "78" "90"
# Ok. Let's check the positions of matches for this regex
m <- gregexpr( '^\\w+\\K,|,(?=\\w+$)' , x , perl = TRUE )
# Matching positions are at
unlist(m)
[1] 4 13
# And extracting them...
regmatches( x , m )
[[1]]
[1] "," ","
Huh?! What is going on?