From this answer to "How do I “think in AngularJS” if I have a jQuery background?":
1. Don't design your page, and then change it with DOM manipulations
In jQuery, you design a page, and then you make it dynamic. This is
  because jQuery was designed for augmentation and has grown incredibly
  from that simple premise.
But in AngularJS, you must start from the ground up with your
  architecture in mind. Instead of starting by thinking "I have this
  piece of the DOM and I want to make it do X", you have to start with
  what you want to accomplish, then go about designing your application,
  and then finally go about designing your view.
2. Don't augment jQuery with AngularJS
Similarly, don't start with the idea that jQuery does X, Y, and Z, so
  I'll just add AngularJS on top of that for models and controllers.
  This is really tempting when you're just starting out, which is why
  I always recommend that new AngularJS developers don't use jQuery at
  all, at least until they get used to doing things the "Angular Way".
I've seen many developers here and on the mailing list create these
  elaborate solutions with jQuery plugins of 150 or 200 lines of code
  that they then glue into AngularJS with a collection of callbacks and
  $applys that are confusing and convoluted; but they eventually get
  it working! The problem is that in most cases that jQuery plugin
  could be rewritten in AngularJS in a fraction of the code, where
  suddenly everything becomes comprehensible and straightforward.
The bottom line is this: when solutioning, first "think in AngularJS";
  if you can't think of a solution, ask the community; if after all of
  that there is no easy solution, then feel free to reach for the
  jQuery. But don't let jQuery become a crutch or you'll never master
  AngularJS.
Which is also true for similar vanilla js plugins.
It doesn't matter whether you write your DOM manipulation / event binding with or without jQuery.
If you have all this code you should probably start with your pure javascript libraries but in some cases you will see that it will be way harder to maintain and extend your widgets.