Uploading files works fine but now I'm trying to validate file extensions and looks like there's some interference 
between FileUpload1 and FileUpload2.
FileUpload1 is used for uploading .jpg or .png images, and FileUpload2 for uploading .pdf files.
Here's the code which is executed on BtnInsert_Click event:
protected void BtnInsert_Click(object sender, EventArgs e)
{
    string[] validPhotoFile = { ".jpg", ".png" };
    string validPDFFile = ".pdf";
    string photoExt = System.IO.Path.GetExtension(FileUpload1.PostedFile.FileName);
    string pdfExt = System.IO.Path.GetExtension(FileUpload2.PostedFile.FileName);
    bool isValidPhotoFile = false;
    bool isValidPDFFile = false;
    for (int i = 0; i < validPhotoFile.Length; i++)
    {
        if (photoExt == "." + validPhotoFile[i])
        {
            isValidPhotoFile = true;
            break;
        }
    }
    for (int i = 0; i < validPDFFile.Length; i++)
    {
        if (pdfExt == "." + validPDFFile[i])
        {
            isValidPDFFile = true;
            break;
        }
    }
    if (!isValidPhotoFile)
    {
        PhotoErrorMessage.Text = "Upload .jpg or .png image!";
    }
    if (!isValidPDFFile)
    {
        PDFErrorMessage.Text = "Upload .pdf file!";
    }
    else
    {
        string photoFilPath = Path.GetFileName(FileUpload1.PostedFile.FileName.ToString());
        string pdfFilPath = Path.GetFileName(FileUpload2.PostedFile.FileName.ToString());
        string photoPath = Server.MapPath(@"~/PDFCover/" + fotoFilPath);
        string pdfPath = Server.MapPath(@"~/PDF/" + pdfFilPath);
        FileUpload1.PostedFile.SaveAs(photoPath);
        FileUpload2.PostedFile.SaveAs(pdfPath);
        SqlCommand cmd = new SqlCommand("INSERT INTO Book(Title,Content...) VALUES ('" + TextBox1.Text
            + "','" + TextBox2.Text + ... + "','" + "~/PDFCover/" + photoFilPath
            + "','" + "~/PDF/" + pdfFilPath + "')", con);
        con.Open();
        cmd.ExecuteNonQuery();
        con.Close();
    }
}
Now even if I choose to upload valid files it's showing label error messages to upload valid files.
 
     
    