I have a unique field, named 'systemCode' within a lot of my models. And I am generating this manually, but also sometimes it can take value from user input, so I have to check this value before saving and if it matches , regenerating this value as a unique value. 
And this is how I generate unique strings at this scenario :
This is my standard class Model :
class ClassOne(models.Model):
   name = models.CharField(max_length=100)
   systemCode = models.CharField(max_length=25, blank=True, null=True, unique=True)
   ....
I am using save() method to generate and check this systemCode is unique : 
    def save(self, *args, **kwargs):
        systemCode = self.systemCode
        if not systemCode:
            systemCode = uuid.uuid4().hex[:6].upper()
        while ClassOne.objects.filter(systemCode=systemCode).exclude(pk=self.pk).exists():
            systemCode = uuid.uuid4().hex[:6].upper()
        self.systemCode = systemCode
        super(ClassOne, self).save(*args, **kwargs)
But I have same systemCode field in all my Models. So I am using a function to generate value. 
So, this is how to generate unique value for all models using saveSystemCode() function : 
import uuid 
def saveSystemCode(inClass, inCode, inPK, prefix):
    systemCode = inCode
    if not systemCode:
        systemCode = uuid.uuid4().hex[:6].upper()
    while inClass.objects.filter(systemCode=systemCode).exclude(pk=inPK).exists():
        systemCode = uuid.uuid4().hex[:6].upper()
    return systemCode
class ClassOne(models.Model):
    name = models.CharField(max_length=100)
    systemCode = models.CharField(max_length=25, blank=True, null=True, unique=True)
    ....
    def save(self, *args, **kwargs):
        self.systemCode = saveSystemCode(ClassOne, self.systemCode, self.pk, 'one_')
        super(ClassOne, self).save(*args, **kwargs)
class ClassTwo(models.Model):
    name = models.CharField(max_length=100)
    systemCode = models.CharField(max_length=25, blank=True, null=True, unique=True)
    ....
    def save(self, *args, **kwargs):
        self.systemCode = saveSystemCode(ClassTwo, self.systemCode, self.pk, 'two_')
        super(ClassTwo, self).save(*args, **kwargs)
class ClassThree(models.Model):
    name = models.CharField(max_length=100)
    systemCode = models.CharField(max_length=25, blank=True, null=True, unique=True)
    ....
    def save(self, *args, **kwargs):
        self.systemCode = saveSystemCode(ClassThree, self.systemCode, self.pk, 'three_')
        super(ClassThree, self).save(*args, **kwargs)
while loop in the 'saveSystemCode' function is preventing to save same value again.