The extension method is called like an instance method, but is actually a static method. The instance pointer "this" is a parameter.
And:
You must specify the this-keyword before the appropriate parameter you want the method to be called upon.
public static class ExtensionMethods
{
    public static string UppercaseFirstLetter(this string value)
    {
        // Uppercase the first letter in the string this extension is called on.
        if (value.Length > 0)
        {
            char[] array = value.ToCharArray();
            array[0] = char.ToUpper(array[0]);
            return new string(array);
        }
        return value;
    }
}
class Program
{
    static void Main()
    {
        // Use the string extension method on this value.
        string value = "dot net perls";
        value = value.UppercaseFirstLetter(); // Called like an instance method.
        Console.WriteLine(value);
    }
}
see http://www.dotnetperls.com/extension for more info.
**Edit: try below example once and again with commenting   
pb.Location=pb.FromCartesian(new Point(20, 20)); 
to see the result**
using System;
using System.Drawing;
using System.Windows.Forms;
namespace WindowsFormsApplication1
{
    public partial class Form1 : Form
    {
        public Form1()
        {
            InitializeComponent();
        }
        private void Form1_Load(object sender, EventArgs e)
        {
            PictureBox pb = new PictureBox();
            pb.Size = new Size(200, 200);
            pb.BackColor = Color.Aqua;
            pb.Location=pb.FromCartesian(new Point(20, 20));
            Controls.Add(pb);
        }
    }
    public static class PictureBoxExtensions
    {
        public static Point ToCartesian(this PictureBox box, Point p)
        {
            return new Point(p.X, p.Y - box.Height);
        }
        public static Point FromCartesian(this PictureBox box, Point p)
        {
            return new Point(p.X, box.Height - p.Y);
        }
    }
}