Here is my code in vb.net below. The problem with this connection string is that the system reads it, compiles it but when I'm trying to pass any input into the database it tells me network instance error.
You see here the original code for the connection:
  Module MyFunction
Public cnn As SqlClient.SqlConnection
Public Sub MakeConnection()
    cnn = New SqlClient.SqlConnection
    If Not cnn.State = ConnectionState.Open Then
        cnn.ConnectionString = System.IO.File.ReadAllText(Application.StartupPath & "\cnn.txt")
        cnn.Open()
    End If 
This gives me error that "executereader is not initialized"
So I changed it like this: 
    Public cnn As SqlClient.SqlConnection
Public Sub MakeConnection()
    cnn = New SqlClient.SqlConnection("Data Source=USARES-PC\SQLEXPRESS;Initial Catalog=HotelDB;Integrated Security=True")
    cnn.Open()
    '  MessageBox.Show("Connection opened!")
End Sub 
I also tried this way:
       Public cnn As SqlClient.SqlConnection
    Public Sub MakeConnection() 
     If cnn.State = ConnectionState.Open Then
        cnn.ConnectionString = "Data Source=USARES-PC\SQLEXPRESS;Initial       Catalog=HotelDB;Integrated Security=True"
          cnn.Close()
        End If