Edit: reqparse is no longer the recommended way to do this with flask-restful!, but there is another example using marshmallow below.
The reqparse object is deprecated. See the docs or the second example in this post for alternatives.
Use reqparse. You can see another example in the flask-restful docs.
It performs validation on the parameters and does not require jsonify.
from flask import Flask
from flask_restful import Resource, Api, reqparse
app = Flask(__name__)
api = Api(app)
class BarAPI(Resource):
    def get(self):
        parser = reqparse.RequestParser()
        parser.add_argument('key1', type=str)
        parser.add_argument('key2', type=str)
        return parser.parse_args()
api.add_resource(BarAPI, '/bar', endpoint='bar')
if __name__ == '__main__':
    app.run(debug=True)
Another way is to use marshmallow.
You can use a Schema class,to validate request.args (for a PUT/POST request you might validate request.form)
from flask import Flask, request, abort
from flask_restful import Resource, Api
from marshmallow import Schema, fields
class BarQuerySchema(Schema):
    key1 = fields.Str(required=True)
    key2 = fields.Str(required=True)
app = Flask(__name__)
api = Api(app)
schema = BarQuerySchema()
class BarAPI(Resource):
    def get(self):
        errors = schema.validate(request.args)
        if errors:
            abort(400, str(errors))
        return 'ok'
api.add_resource(BarAPI, '/bar', endpoint='bar')
# omit of you intend to use `flask run` command
if __name__ == '__main__':
    app.run(debug=True)
This example requires that both parameters be present.