Assuming sender_id and receiver_id are references to a user_id, and assuming that user_id is UNIQUE in the Users table... yes.
Join to the Users table twice.
For example:
  SELECT t.sender_id
       , t.receiver_id
       , t.value
       , s.user_id   AS sender_user_id
       , s.username  AS sender_username
       , r.user_id   AS receiver_user_id
       , r.username  AS receiver_username
    FROM `Transactions` t
    LEFT
    JOIN `Users` s ON s.user_id = t.sender_id 
    LEFT
    JOIN `Users` r ON r.user_id = t.receiver_id
   ORDER BY 1,2,3
The query is using outer joins... the row from Transactions will be returned if receiver_id or sender_id doesn't match a row in the Users table.
The keyword LEFT can be removed to change that behavior, so a row will be returned only if there is a matching row in Users for both sender_id and receiver_id.