It is possible. An example is below.
const http = require('http');
const fs = require('fs');
const filename = "logo.jpg";
const boundary = "MyBoundary12345";
fs.readFile(filename, function (err, content) {
    if (err) {
        console.log(err);
        return
    }
    let data = "";
    data += "--" + boundary + "\r\n";
    data += "Content-Disposition: form-data; name=\"file1\"; filename=\"" + filename + "\"\r\nContent-Type: image/jpeg\r\n";
    data += "Content-Type:application/octet-stream\r\n\r\n";
    const payload = Buffer.concat([
        Buffer.from(data, "utf8"),
        Buffer.from(content, 'binary'),
        Buffer.from("\r\n--" + boundary + "--\r\n", "utf8"),
    ]);
    const options = {
        host: "localhost",
        port: 8080,
        path: "/upload",
        method: 'POST',
        headers: {
            "Content-Type": "multipart/form-data; boundary=" + boundary,
        },
    }
    const chunks = [];
    const req = http.request(options, response => {
        response.on('data', (chunk) => chunks.push(chunk));
        response.on('end', () => console.log(Buffer.concat(chunks).toString()));
    });
    req.write(payload)
    req.end()
})
The question is interesting. I wonder why it is not already answered (4 years, 9 months).