To support iOS 11.x and lower, I extended the UIStackView like Enrique mentioned, however I modified it to include:
- Adding a space before the arrangedSubview
- Handling cases where a space already exists and just needs to be updated
- Removing an added space
extension UIStackView {
    func addSpacing(_ spacing: CGFloat, after arrangedSubview: UIView) {
        if #available(iOS 11.0, *) {
            setCustomSpacing(spacing, after: arrangedSubview)
        } else {
            let index = arrangedSubviews.firstIndex(of: arrangedSubview)
            if let index = index, arrangedSubviews.count > (index + 1), arrangedSubviews[index + 1].accessibilityIdentifier == "spacer" {
                arrangedSubviews[index + 1].updateConstraint(axis == .horizontal ? .width : .height, to: spacing)
            } else {
                let separatorView = UIView(frame: .zero)
                separatorView.accessibilityIdentifier = "spacer"
                separatorView.translatesAutoresizingMaskIntoConstraints = false
                switch axis {
                case .horizontal:
                    separatorView.widthAnchor.constraint(equalToConstant: spacing).isActive = true
                case .vertical:
                    separatorView.heightAnchor.constraint(equalToConstant: spacing).isActive = true
                @unknown default:
                    return
                }
                if let index = index {
                    insertArrangedSubview(separatorView, at: index + 1)
                }
            }
        }
    }
    func addSpacing(_ spacing: CGFloat, before arrangedSubview: UIView) {
        let index = arrangedSubviews.firstIndex(of: arrangedSubview)
        if let index = index, index > 0, arrangedSubviews[index - 1].accessibilityIdentifier == "spacer" {
            let previousSpacer = arrangedSubviews[index - 1]
            switch axis {
            case .horizontal:
                previousSpacer.updateConstraint(.width, to: spacing)
            case .vertical:
                previousSpacer.updateConstraint(.height, to: spacing)
            @unknown default: return // Incase NSLayoutConstraint.Axis is extended in future
            }
        } else {
            let separatorView = UIView(frame: .zero)
            separatorView.accessibilityIdentifier = "spacer"
            separatorView.translatesAutoresizingMaskIntoConstraints = false
            switch axis {
            case .horizontal:
                separatorView.widthAnchor.constraint(equalToConstant: spacing).isActive = true
            case .vertical:
                separatorView.heightAnchor.constraint(equalToConstant: spacing).isActive = true
            @unknown default:
                return
            }
            if let index = index {
                insertArrangedSubview(separatorView, at: max(index - 1, 0))
            }
        }
    }
    func removeSpacing(after arrangedSubview: UIView) {
        if #available(iOS 11.0, *) {
            setCustomSpacing(0, after: arrangedSubview)
        } else {
            if let index = arrangedSubviews.firstIndex(of: arrangedSubview), arrangedSubviews.count > (index + 1), arrangedSubviews[index + 1].accessibilityIdentifier == "spacer" {
                arrangedSubviews[index + 1].removeFromStack()
            }
        }
    }
    func removeSpacing(before arrangedSubview: UIView) {
        if let index = arrangedSubviews.firstIndex(of: arrangedSubview), index > 0, arrangedSubviews[index - 1].accessibilityIdentifier == "spacer" {
            arrangedSubviews[index - 1].removeFromStack()
        }
    }
}
extension UIView {
    func updateConstraint(_ attribute: NSLayoutConstraint.Attribute, to constant: CGFloat) {
        for constraint in constraints {
            if constraint.firstAttribute == attribute {
              constraint.constant = constant
            }
        }
    }
    func removeFromStack() {
        if let stack = superview as? UIStackView, stack.arrangedSubviews.contains(self) {
            stack.removeArrangedSubview(self)
            // Note: 1
            removeFromSuperview()
        }
    }
}
Note: 1 - According to the documentation: 
To prevent the view from appearing on screen after calling the stack’s
  removeArrangedSubview: method, explicitly remove the view from the
  subviews array by calling the view’s removeFromSuperview() method, or
  set the view’s isHidden property to true.