This is the method I used in my project:
//use a Property or Field for keeping the info to avoid runtime computation
public static bool NotInDesignMode { get; } = IsNotInDesignMode();
private static bool IsNotInDesignMode()
{
    /*
    File.WriteAllLines(@"D:\1.log", new[]
    {
        LicenseManager.UsageMode.ToString(), //not always reliable, e.g. WPF app in Blend this will return RunTime
        Process.GetCurrentProcess().ProcessName, //filename without extension
        Process.GetCurrentProcess().MainModule.FileName, //full path
        Process.GetCurrentProcess().MainModule.ModuleName, //filename
        Assembly.GetEntryAssembly()?.Location, //null for WinForms app in VS IDE
        Assembly.GetEntryAssembly()?.ToString(), //null for WinForms app in VS IDE
        Assembly.GetExecutingAssembly().Location, //always return your project's output assembly info
        Assembly.GetExecutingAssembly().ToString(), //always return your project's output assembly info
    });
    //*/
    //LicenseManager.UsageMode will return RunTime if LicenseManager.context is not present.
    //So you can not return true by judging it's value is RunTime.
    if (LicenseUsageMode.Designtime == LicenseManager.UsageMode) return false;
    var procName = Process.GetCurrentProcess().ProcessName.ToLower();
    return "devenv" != procName //WinForms app in VS IDE
        && "xdesproc" != procName //WPF app in VS IDE/Blend
        && "blend" != procName //WinForms app in Blend
        //other IDE's process name if you detected by log from above
        ;
}
Attention!!!: The code returned bool is indicating NOT in design mode!