If you want to selectively apply the one-click editing to certain columns, you can switch the current cell during the MouseDown event to eliminate the click to edit:
// Subscribe to DataGridView.MouseDown when convenient
this.dataGridView.MouseDown += this.HandleDataGridViewMouseDown;
private void HandleDataGridViewMouseDown(object sender, MouseEventArgs e)
{
    // See where the click is occurring
    DataGridView.HitTestInfo info = this.dataGridView.HitTest(e.X, e.Y);
    if (info.Type == DataGridViewHitTestType.Cell)
    {
        switch (info.ColumnIndex)
        {
            // Add and remove case statements as necessary depending on
            // which columns have ComboBoxes in them.
            case 1: // Column index 1
            case 2: // Column index 2
                this.dataGridView.CurrentCell =
                    this.dataGridView.Rows[info.RowIndex].Cells[info.ColumnIndex];
                break;
            default:
                break;
        }
    }
}
Of course, if your columns and their indexes are dynamic, you would need to modify this a bit.