Here is the minimum code necessary to get it running, I think. I got the main code, slightly modified, from Using PhotoSwipe with jQuery. Plus I added a function from the documentation to enable the zooming effect when you click on a thumbnail, since I figured that is part of the necessary coolness of PhotoSwipe. It assumes your thumbnails are in a container with a class of "thumbnail" (line 1), and it assumes that inside the thumbnail container are simple a tags (line 5 and 23). It also does nothing to dynamically load the PhotoSwipe HTML, I just pasted it at the bottom of my page. I will ultimately include it as a PHP snippet. I am sure that with a bit more work this code could be incorporated into the main PhotoSwipe js and it could be intitalized with something as simple as $('.my-gallery').photoswipe({options}). That would be nice.
Oh, additionally, to get it working at all you will need to include the photoswipe.css and "default-skin" files from here https://github.com/dimsemenov/PhotoSwipe/tree/master/dist.
$('.thumbnails').each( function() {
        var $pic     = $(this),
            getItems = function() {
                var items = [];
                $pic.find('a').each(function() {
                    var $href   = $(this).attr('href'),
                        $size   = $(this).data('size').split('x'),
                        $width  = $size[0],
                        $height = $size[1];
                    var item = {
                        src : $href,
                        w   : $width,
                        h   : $height
                    }
                    items.push(item);
                });
                return items;
            }
        var items = getItems();
        var $pswp = $('.pswp')[0];
        $pic.on('click','a',function(event) {
            event.preventDefault();
            var $index = $(this).index();
            var thumbnail = $(this)[0]
            var options = {
                index: $index,
                bgOpacity: 0.7,
                showHideOpacity: true,
                getThumbBoundsFn: function(index) {
                    // get window scroll Y
                    var pageYScroll = window.pageYOffset || document.documentElement.scrollTop;
                    // optionally get horizontal scroll
                    // get position of element relative to viewport
                    var rect = thumbnail.getBoundingClientRect();
                    // w = width
                    return {x:rect.left, y:rect.top + pageYScroll, w:rect.width};
                }
            }
            // Initialize PhotoSwipe
            var lightBox = new PhotoSwipe($pswp, PhotoSwipeUI_Default, items, options);
            lightBox.init();
        })
    })