I have reg exp for match some data (is it here) and now I try to replace all matched data with single : characetr  
test_str = u"THERE IS MY DATA"
p = re.compile(ur'[a-z]+([\n].*?<\/div>[\n ]+<div class="large-3 small-3 columns">[\n ]+)[a-z]+', re.M|re.I|re.SE) 
print re.sub(p, r':/1',test_str) 
I try it on few other way but it's not replace any or replace not only matched but whole pattern
 
    