The below hardcodes the pattern.
It looks for the first character that is not one of the characters to exclude at both ends.
To make it dynamic you could build up the set of characters using string concatenation (be careful of characters containing special meaning in the pattern syntax)
WITH T(String) AS
(
SELECT 'Computation+Time, Cost،,.?!؛,،,><=+ـ' union all
SELECT ',,,,,!؛Computation+Time, Cost،,.?!؛,،,><=+ـ' union all
SELECT 'Computation+Time, Cost،,.?!؛,،,><=+ـ' union all
SELECT 'Computation+Time, Cost' union all
SELECT ''
)
SELECT SUBSTRING(String,Start,len(String) + 2 - Start - Finish)
FROM T
CROSS APPLY
(
SELECT PATINDEX('%[^،,.?!؛,،,><=+ـ]%' COLLATE Latin1_General_Bin,String),
PATINDEX('%[^،,.?!؛,،,><=+ـ]%' COLLATE Latin1_General_Bin,REVERSE(String))
)ca(Start, Finish)