Using the aws-sdk module and Express 4.13, it's possible to proxy a file from S3 a number of ways.
This callback version will return the file body as a buffer, plus other relevant headers like Content-Length:
function(req,res){
  var s3 = new AWS.S3();
  s3.getObject({Bucket: myBucket, Key: myFile},function(err,data){
    if (err) {
      return res.status(500).send("Error!");
    }
    // Headers
    res.set("Content-Length",data.ContentLength)
       .set("Content-Type",data.ContentType);
    res.send(data.Body); // data.Body is a buffer
  });
}
The problem with this version is that you have to get the entire file before sending it, which is not great, especially if it's something large like a video.
This version will directly stream the file:
function(req,res){
  var s3 = new AWS.S3();
  s3.getObject({Bucket: myBucket, Key: myFile})
    .createReadStream()
    .pipe(res);
}
But unlike the first one, it won't do anything about the headers, which a browser might need to properly handle the file.
Is there a way to get the best of both worlds, passing through the correct headers from S3 but sending the file as a stream?  It could be done by first making a HEAD request to S3 to get the metadata, but can it be done with one API call?