I wrote my own module for it. I called it cute_profile. Here is the code. Here are the tests.
Here is the blog post explaining how to use it.
It's part of GarlicSim, so if you want to use it you can install garlicsim and do from garlicsim.general_misc import cute_profile.
If you want to use it on Python 3 code, just install the Python 3 fork of garlicsim.
Here's an outdated excerpt from the code:
import functools
from garlicsim.general_misc import decorator_tools
from . import base_profile
def profile_ready(condition=None, off_after=True, sort=2):
    '''
    Decorator for setting a function to be ready for profiling.
    For example:
        @profile_ready()
        def f(x, y):
            do_something_long_and_complicated()
    The advantages of this over regular `cProfile` are:
     1. It doesn't interfere with the function's return value.
     2. You can set the function to be profiled *when* you want, on the fly.
    How can you set the function to be profiled? There are a few ways:
    You can set `f.profiling_on=True` for the function to be profiled on the
    next call. It will only be profiled once, unless you set
    `f.off_after=False`, and then it will be profiled every time until you set
    `f.profiling_on=False`.
    You can also set `f.condition`. You set it to a condition function taking
    as arguments the decorated function and any arguments (positional and
    keyword) that were given to the decorated function. If the condition
    function returns `True`, profiling will be on for this function call,
    `f.condition` will be reset to `None` afterwards, and profiling will be
    turned off afterwards as well. (Unless, again, `f.off_after` is set to
    `False`.)
    `sort` is an `int` specifying which column the results will be sorted by.
    '''
    def decorator(function):
        def inner(function_, *args, **kwargs):
            if decorated_function.condition is not None:
                if decorated_function.condition is True or \
                   decorated_function.condition(
                       decorated_function.original_function,
                       *args,
                       **kwargs
                       ):
                    decorated_function.profiling_on = True
            if decorated_function.profiling_on:
                if decorated_function.off_after:
                    decorated_function.profiling_on = False
                    decorated_function.condition = None
                # This line puts it in locals, weird:
                decorated_function.original_function
                base_profile.runctx(
                    'result = '
                    'decorated_function.original_function(*args, **kwargs)',
                    globals(), locals(), sort=decorated_function.sort
                )                
                return locals()['result']
            else: # decorated_function.profiling_on is False
                return decorated_function.original_function(*args, **kwargs)
        decorated_function = decorator_tools.decorator(inner, function)
        decorated_function.original_function = function
        decorated_function.profiling_on = None
        decorated_function.condition = condition
        decorated_function.off_after = off_after
        decorated_function.sort = sort
        return decorated_function
    return decorator