For pure CSS solution, use label and input[type = "checkbox"] combination.  (code pen: http://codepen.io/anon/pen/dXXXww).
HTML:
<input type = "checkbox" id = "buttonState" class = "btn-state" />
<label for = "buttonState" class = "btn">
  Save
</label>
CSS (LESS):
.btn {
  box-sizing: border-box;
  display: inline-block;
  font: normal 20px/40px Sans-serif;
  text-align: center;
  width: 100px;
  height: 40px;
  background-color: yellow;
  border-radius: 10px;
  cursor: pointer;
}
.btn-state {
  display: none;
  &:checked + .btn {
    animation: example 4s infinite;
  }
}
@keyframes example {
  0%   {background-color: yellow;}
  50%  {background-color: green;}
}
For a JavaScript solution, use the code below.  (code pen: http://codepen.io/anon/pen/OXXXqP).
HTML:
<button class = "btn">
  Save
</button>
CSS:
.btn {
  box-sizing: border-box;
  display: inline-block;
  font: normal 20px/40px Sans-serif;
  text-align: center;
  width: 100px;
  height: 40px;
  background-color: yellow;
  border-radius: 10px;
  cursor: pointer;
  outline: 0;
}
.btn.animate {
  animation: example 4s infinite;
}
@keyframes example {
  0%   {background-color: yellow;}
  50%  {background-color: green;}
}
JS:
var $ = document.querySelectorAll.bind(document);
$('.btn')[0].addEventListener('click', function(evt) {
  evt.target.classList.toggle('animate');
});