Scenario: Chrome v51.0.2704, Bootstrap v2.3.2, Windows 10 v1511. See snippet below. I've excluded the Bootstrap CSS that does not apply to this case.
Problem: As can be seen when rapidly moving the mouse on and off of the element, the background appears to randomly "flicker" with light blue horizontal lines appearing for just a moment.
This does not seem to occur on Firefox v46, IE v11, or Edge v25.
button,
input,
select,
textarea {
  margin: 0;
  font-size: 100%;
  vertical-align: middle;
}
button,
input {
  *overflow: visible;
  line-height: normal;
}
button::-moz-focus-inner,
input::-moz-focus-inner {
  padding: 0;
  border: 0;
}
button,
html input[type="button"],
input[type="reset"],
input[type="submit"] {
  cursor: pointer;
  -webkit-appearance: button;
}
label,
select,
button,
input[type="button"],
input[type="reset"],
input[type="submit"],
input[type="radio"],
input[type="checkbox"] {
  cursor: pointer;
}
label,
input,
button,
select,
textarea {
  font-size: 14px;
  font-weight: normal;
  line-height: 20px;
}
input,
button,
select,
textarea {
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
}
input,
textarea,
.uneditable-input {
  width: 206px;
}
input[type="file"],
input[type="image"],
input[type="submit"],
input[type="reset"],
input[type="button"],
input[type="radio"],
input[type="checkbox"] {
  width: auto;
}
input:-moz-placeholder,
textarea:-moz-placeholder {
  color: #999999;
}
input:-ms-input-placeholder,
textarea:-ms-input-placeholder {
  color: #999999;
}
input::-webkit-input-placeholder,
textarea::-webkit-input-placeholder {
  color: #999999;
}
input,
textarea,
.uneditable-input {
  margin-left: 0;
}
.btn {
  display: inline-block;
  *display: inline;
  padding: 4px 12px;
  margin-bottom: 0;
  *margin-left: .3em;
  font-size: 14px;
  line-height: 20px;
  color: #333333;
  text-align: center;
  text-shadow: 0 1px 1px rgba(255, 255, 255, 0.75);
  vertical-align: middle;
  cursor: pointer;
  background-color: #f5f5f5;
  *background-color: #e6e6e6;
  background-image: -moz-linear-gradient(top, #ffffff, #e6e6e6);
  background-image: -webkit-gradient(linear, 0 0, 0 100%, from(#ffffff), to(#e6e6e6));
  background-image: -webkit-linear-gradient(top, #ffffff, #e6e6e6);
  background-image: -o-linear-gradient(top, #ffffff, #e6e6e6);
  background-image: linear-gradient(to bottom, #ffffff, #e6e6e6);
  background-repeat: repeat-x;
  border: 1px solid #cccccc;
  *border: 0;
  border-color: #e6e6e6 #e6e6e6 #bfbfbf;
  border-color: rgba(0, 0, 0, 0.1) rgba(0, 0, 0, 0.1) rgba(0, 0, 0, 0.25);
  border-bottom-color: #b3b3b3;
  -webkit-border-radius: 4px;
     -moz-border-radius: 4px;
          border-radius: 4px;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#ffffffff', endColorstr='#ffe6e6e6', GradientType=0);
  filter: progid:DXImageTransform.Microsoft.gradient(enabled=false);
  *zoom: 1;
  -webkit-box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.2), 0 1px 2px rgba(0, 0, 0, 0.05);
     -moz-box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.2), 0 1px 2px rgba(0, 0, 0, 0.05);
          box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.2), 0 1px 2px rgba(0, 0, 0, 0.05);
}
.btn:hover,
.btn:focus,
.btn:active,
.btn.active,
.btn.disabled,
.btn[disabled] {
  color: #333333;
  background-color: #e6e6e6;
  *background-color: #d9d9d9;
}
.btn:first-child {
  *margin-left: 0;
}
.btn:hover,
.btn:focus {
  color: #333333;
  text-decoration: none;
  background-position: 0 -15px;
  -webkit-transition: background-position 0.1s linear;
     -moz-transition: background-position 0.1s linear;
       -o-transition: background-position 0.1s linear;
          transition: background-position 0.1s linear;
}
.btn-large {
  padding: 11px 19px;
  font-size: 17.5px;
  -webkit-border-radius: 6px;
     -moz-border-radius: 6px;
          border-radius: 6px;
}
.btn-primary {
  color: #ffffff;
  text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.25);
  background-color: #006dcc;
  *background-color: #0044cc;
  background-image: -moz-linear-gradient(top, #0088cc, #0044cc);
  background-image: -webkit-gradient(linear, 0 0, 0 100%, from(#0088cc), to(#0044cc));
  background-image: -webkit-linear-gradient(top, #0088cc, #0044cc);
  background-image: -o-linear-gradient(top, #0088cc, #0044cc);
  background-image: linear-gradient(to bottom, #0088cc, #0044cc);
  background-repeat: repeat-x;
  border-color: #0044cc #0044cc #002a80;
  border-color: rgba(0, 0, 0, 0.1) rgba(0, 0, 0, 0.1) rgba(0, 0, 0, 0.25);
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#ff0088cc', endColorstr='#ff0044cc', GradientType=0);
  filter: progid:DXImageTransform.Microsoft.gradient(enabled=false);
}
.btn-primary:hover,
.btn-primary:focus,
.btn-primary:active,
.btn-primary.active,
.btn-primary.disabled,
.btn-primary[disabled] {
  color: #ffffff;
  background-color: #0044cc;
  *background-color: #003bb3;
}
button.btn,
input[type="submit"].btn {
  *padding-top: 3px;
  *padding-bottom: 3px;
}
button.btn::-moz-focus-inner,
input[type="submit"].btn::-moz-focus-inner {
  padding: 0;
  border: 0;
}
button.btn.btn-large,
input[type="submit"].btn.btn-large {
  *padding-top: 7px;
  *padding-bottom: 7px;
}<input type="submit" name="submit" class="btn btn-primary btn-lg"> 
     
     
    