No, unfortunately. You will have to settle for floats. 
>>> s = pd.Series(['1', '2', '3', '4', '5'], index=list('abcde'))
>>> s
a    1
b    2
c    3
d    4
e    5
dtype: object
>>> s = s.reindex(['a','b','c','f','u'])
>>> s
a      1
b      2
c      3
f    NaN
u    NaN
dtype: object
>>> s.astype(int)
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
  File "/home/juan/anaconda3/lib/python3.5/site-packages/pandas/core/generic.py", line 2947, in astype
    raise_on_error=raise_on_error, **kwargs)
  File "/home/juan/anaconda3/lib/python3.5/site-packages/pandas/core/internals.py", line 2873, in astype
    return self.apply('astype', dtype=dtype, **kwargs)
  File "/home/juan/anaconda3/lib/python3.5/site-packages/pandas/core/internals.py", line 2832, in apply
    applied = getattr(b, f)(**kwargs)
  File "/home/juan/anaconda3/lib/python3.5/site-packages/pandas/core/internals.py", line 422, in astype
    values=values, **kwargs)
  File "/home/juan/anaconda3/lib/python3.5/site-packages/pandas/core/internals.py", line 465, in _astype
    values = com._astype_nansafe(values.ravel(), dtype, copy=True)
  File "/home/juan/anaconda3/lib/python3.5/site-packages/pandas/core/common.py", line 2628, in _astype_nansafe
    return lib.astype_intsafe(arr.ravel(), dtype).reshape(arr.shape)
  File "pandas/lib.pyx", line 937, in pandas.lib.astype_intsafe (pandas/lib.c:16620)
  File "pandas/src/util.pxd", line 60, in util.set_value_at (pandas/lib.c:67979)
ValueError: cannot convert float NaN to integer
From Pandas Caveats and Gotchas:
The special value NaN (Not-A-Number) is used everywhere as the NA
  value, and there are API functions isnull and notnull which can be
  used across the dtypes to detect NA values.
However, it comes with it a couple of trade-offs which I most
  certainly have not ignored... In the absence of high performance NA
  support being built into NumPy from the ground up, the primary
  casualty is the ability to represent NAs in integer arrays.
So work with this:
>>> s.astype(float)
a    1.0
b    2.0
c    3.0
f    NaN
u    NaN
dtype: float64