EDIT - With Regex:
CGRectMake\(([^,]*),([^,]*),([^,]*),([a-z|0-9|.|A-Z]*)\)
and replace with 
CGRect\(x:\1, y:\2, width:\3, height:\4\)
Using regex we can not get the value of x,y,width,height dynamically.
So Alternative solution to above is,
- Replace all the 
CGRectMake( with
appdelegateobject.CGRectMakeWrapper("  
- At the end add 
" only. 
Means in your case you will replace CGRectMake(a,a,a,a) to appdelegateobject.CGRectMakeWrapper("a,a,a,a"
where appdelegateobject is the appdelegate shared instance object where you will define CGRectMakeWrapper function having string parameter as shown below :
func CGRectMakeWrapper(str: String) -> CGRect {
    var rect = CGRectZero
    if(str.characters.count > 0)
    {
        var arr = str.componentsSeparatedByString(",")
        if(arr.count == 4)
        {
            rect = CGRect(x: CGFloat((arr[0] as NSString).doubleValue), y: CGFloat((arr[1] as NSString).doubleValue), width: CGFloat((arr[2] as NSString).doubleValue), height: CGFloat((arr[3] as NSString).doubleValue))
        }
    }
    return rect
}
var rect = "10.0,10.0,100,100" //String
var rect1 = CGRectMakeWrapper(rect)  //CGRect
I have shown sample string as rect and passed to CGRectMakeWrapper function which will return a rect. You can define this CGRectMakeWrapper function in common class which is accessible to all classes(e.g Appdelegate file).