You can use Array.prototype.every()
var check = [item, item.integrations, item.integrations.slackData]
            .every(function(element) { return element });
Edit, Updated
As noted at comments by @FelixKling, the pattern at above using .every() will fail if item.integrations is undefined.
Given the example object at Question you can use JSON.stringify(), String.prototype.match() with RegExp /"integrations":|"slackData":|"url":/g/, then check that .length of resulting array, if any, is equal to the number of properties expected; in the present case 3.
A javascript object which is passed to JSON.stringify() should have properties with the following pattern:
" followed by property followed by " followed by :. Depending on the source object, the RegExp can be further adjusted to meet the specific properties and values of that object.
JSON.stringify(item).match(/"integrations":|"slackData":|"url":/g).length === 3
Note that JSON.stringify() has a replacer option which can be used to match properties of the object. The replacer function option is recursive. See also
but I'm wondering if there's a better way to do this kind of check in
  ES6:
The present Answer does not attempt to indicate that using JSON.stringify() and RegExp to match or filter a javascript object is "better"; but only that the approach can meet the described requirement at the present Question.