It is possible to achieve this with a few tricks. Given
typedef enum
{
  BLUE,
  RED
} color_t;
Then define a dummy union which won't be used by the caller, but contains members with the same names as the enumeration constants:
typedef union
{
  color_t BLUE;
  color_t RED;
} typesafe_color_t;
This is possible because enumeration constants and member/variable names reside in different namespaces.
Then make some function-like macros:
#define c_assign(var, val) (var) = (typesafe_color_t){ .val = val }.val
#define color_assign(var, val) _Generic((var), color_t: c_assign(var, val))
These macros are then called like this:
color_t color;
color_assign(color, BLUE); 
Explanation:  
- The C11 _Generickeyword ensures that the enumeration variable is of the correct type. However, this can't be used on the enumeration constantBLUEbecause it is of typeint.
- Therefore the helper macro c_assigncreates a temporary instance of the dummy union, where the designated initializer syntax is used to assign the valueBLUEto a union member namedBLUE. If no such member exists, the code won't compile.
- The union member of the corresponding type is then copied into the enum variable.
We actually don't need the helper macro, I just split the expression for readability. It works just as fine to write
#define color_assign(var, val) _Generic((var), \
color_t: (var) = (typesafe_color_t){ .val = val }.val )
Examples:
color_t color; 
color_assign(color, BLUE);// ok
color_assign(color, RED); // ok
color_assign(color, 0);   // compiler error 
int x;
color_assign(x, BLUE);    // compiler error
typedef enum { foo } bar;
color_assign(color, foo); // compiler error
color_assign(bar, BLUE);  // compiler error
EDIT
Obviously the above doesn't prevent the caller from simply typing color = garbage;. If you wish to entirely block the possibility of using such assignment of the enum, you can put it in a struct and use the standard procedure of private encapsulation with "opaque type":
color.h
#include <stdlib.h>
typedef enum
{
  BLUE,
  RED
} color_t;
typedef union
{
  color_t BLUE;
  color_t RED;
} typesafe_color_t;
typedef struct col_t col_t; // opaque type
col_t* col_alloc (void);
void   col_free (col_t* col);
void col_assign (col_t* col, color_t color);
#define color_assign(var, val)   \
  _Generic( (var),               \
    col_t*: col_assign((var), (typesafe_color_t){ .val = val }.val) \
  )
color.c
#include "color.h"
struct col_t
{
  color_t color;
};
col_t* col_alloc (void) 
{ 
  return malloc(sizeof(col_t)); // (needs proper error handling)
}
void col_free (col_t* col)
{
  free(col);
}
void col_assign (col_t* col, color_t color)
{
  col->color = color;
}
main.c
col_t* color;
color = col_alloc();
color_assign(color, BLUE); 
col_free(color);