When setting up an OxyPlot plot view, you can either define the plot explicitly through various controls, or set it up through a binding to a PlotModel.
As such, in the first case, the XAML for a plot of two LineSeries objects could look something like
<oxy:Plot Title="Some plot">
    <oxy:Plot.Axes>
        <oxy:LinearAxis Position="Left" />
        <oxy:LinearAxis Position="Bottom" />
    </oxy:Plot.Axes>
    <oxy:Plot.Series>
        <oxy:LineSeries ItemsSource="{Binding ActualSeriesData1}" DataFieldX="X" DataFieldY="Y"/>
        <oxy:LineSeries ItemsSource="{Binding ActualSeriesData2}" DataFieldX="X" DataFieldY="Y"/>
    </oxy:Plot.Series>
</oxy:Plot>
with a very thin view-model. On the other hand, in the second case, I would simply have something like
<oxy:PlotView Model="{Binding SomePlotModel}" />
and construct the actual plot in the view-model. There are pros and cons to both setups, but I find that the first approach generally works better when I know beforehand what I actually want to plot, whereas the second approach allows for dynamic changes to the plot contents.
My issue is the following: For the first case I know how to add general styling to all plots. If, for instance, I want them to make them look Seaborn-like, I would just add something like
<x:Array Type="Color" x:Key="SeabornColors">
    <Color>#4c72b0</Color>
    <Color>#55a868</Color>
    <Color>#c44e52</Color>
    <Color>#8172b2</Color>
    <Color>#ccb974</Color>
    <Color>#64b5cd</Color>
</x:Array>
<Style TargetType="oxy:Plot">
    <Setter Property="PlotAreaBackground" Value="#EBEBF2" />
    <Setter Property="PlotAreaBorderThickness" Value="0" />
    <Setter Property="TitleFont" Value="Segoe UI" />
    <Setter Property="TitleFontWeight" Value="Normal" />
    <Setter Property="DefaultColors" Value="{StaticResource SeabornColors}"/>
</Style>
<Style TargetType="oxy:LinearAxis">
    <Setter Property="TicklineColor" Value="White" />
    <Setter Property="MajorGridlineColor" Value="White" />
    <Setter Property="MinorGridlineColor" Value="White" />
    <Setter Property="ExtraGridlineColor" Value="White" />
    <Setter Property="AxislineColor" Value="White" />
    <Setter Property="TitleColor" Value="Black" />
    <Setter Property="TextColor" Value="Black" />
    <Setter Property="Font" Value="Segoe UI" />
    <Setter Property="TitleFont" Value="Segoe UI" />
    <Setter Property="TickStyle" Value="None" />
    <Setter Property="MajorGridlineStyle" Value="Solid" />
</Style>
to my ResourceDictionary. How can I achieve the same effect in the second case, i.e. using an oxy:PlotView? I can set some of the general styling properties using a <Style TargetType="oxy:PlotView" />, but how would I style, say, all LineSeries contained within a Series within a Model within a PlotView?
 
    