You can actually use expr in POSIX shell do what you need as well, e.g.
while read -r line; do 
    len=$(expr match "$line" [0-9][0-9]*[A-Za-z]*)
    [ "$len" -gt '0' ] && expr substr "$line" 1 $len || 
    printf "%s\n" "$line"
done < file
With your data in file, just cut and paste the above into the command line, e.g.
$ while read -r line; do
>     len=$(expr match "$line" [0-9][0-9]*[A-Za-z]*)
>     [ "$len" -gt '0' ] && expr substr "$line" 1 $len ||
>     printf "%s\n" "$line"
> done < file
one1
2two
45end
note: while this is a solution using expr match and expr substr, the sed solutions are more efficient as you will spawn a separate subshell on each expr call. (but it is good to know the alternatives...)