Way 1. How Override high DPI scaling (check checkbox) with registry
Start up Registry Editor and navigate to this key:
HKEY_CURRENT_USER\Software\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers
Now add a string value (REG_SZ) whose name is the full path to the application executable and whose value is HIGHDPIAWARE
Code example:
string appPath = string.Format(@"{0}\{1}.exe", My.Application.Info.DirectoryPath, My.Application.Info.AssemblyName);       
My.Computer.Registry.SetValue(@"HKEY_CURRENT_USER\Software\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers", appPath, "HIGHDPIAWARE");
Read more: High DPI Settings in Windows
Way 2. How to change DPI-aware in assembly manifest?
DPI-aware applications are not affected by the OS. Such applications render themselves to fit the actual DPI of a screen and provide a much better visual experience.
Add the <dpiAware> element to the manifest code and set its value to true.
<?xml version="1.0" encoding="utf-8"?>
<assembly xmlns="urn:schemas-microsoft-com:asm.v1" manifestVersion="1.0" xmlns:asmv3="urn:schemas-microsoft-com:asm.v3" >
    <assemblyIdentity version="1.0.0.0" name="MyApplication.app"/>
    <trustInfo xmlns="urn:schemas-microsoft-com:asm.v2">
        <security>
            <requestedPrivileges xmlns="urn:schemas-microsoft-com:asm.v3">
                <requestedExecutionLevel level="asInvoker" uiAccess="false" />
            </requestedPrivileges>
        </security>
    </trustInfo>
    <asmv3:application>
        <asmv3:windowsSettings xmlns="http://schemas.microsoft.com/SMI/2005/WindowsSettings">
             <dpiAware>true</dpiAware> 
        </asmv3:windowsSettings>
    </asmv3:application>
</assembly>
Additional resources:
- High DPI Support 
- High DPI Desktop Application Development on Windows (also Application Manifests) 
- DPI Awareness - Unaware in one Release, System Aware in the Other [duplicate] 
- Writing High-DPI Aware Windows Apps 
- Writing DPI-Aware Desktop and Win32 Applications