I have the following Method that gets the posted files.
What is the best approach to calculate the MD5 hash and where ? 
    public void ProcessRequest(HttpContext context)
    {
        if (context.Request.Files.Count > 0)
        {
            HttpFileCollection files = context.Request.Files;
            for (int i = 0; i < files.Count; i++)
            {
                HttpPostedFile file = files[i];
                string fileName = context.Server.MapPath("~/uploads/" + file.FileName);
                file.SaveAs(fileName);
                int Size = file.ContentLength;
            }
        }
    }