I'll assume that you have a column col in table t, and col is CHARACTER SET utf8 (or utf8mb4).
SELECT ...
FROM t
WHERE HEX(col) REGEXP '^(..)*CCA3'
Will locate all lines with U+0323 (encoded as UTF-8 CCA3).
Alas, there is no easy way to modify col in SQL.
If you have MariaDB, then UNHEX(REGEXP_REPLACE(HEX(col), 'CCA3', '')) will almost work. The problem is that it could be misaligned (at an odd boundary).
Another thought: REPLACE(col, UNHEX('CCA3'), '') might work in MySQL or MariaDB. However, it could get into issues with Collations. So, perhaps this would work: REPLACE(col COLLATE utf8_bin, UNHEX('CCA3'), '')