In order to bypass all interceptors we can use HttpBackend as @deg suggested.
In other cases we can create HttpClient factory that will allows us to exclude interceptors from the interceptors chain:
import { createHttpClient } from './http-client.factory';
// ...
@Injectable({
  providedIn: 'root'
})
export class TodosApiService {
  http = createHttpClient(this.injector, [Interceptor2]);
//                                        ^^^^^^^^^^^^
//                                    Interceptors to exclude
  constructor(private injector: Injector) { }
  getTodo() {
    // Interceptor2 will be bypassed
    return this.http.get('https://jsonplaceholder.typicode.com/todos')
  }
}
Ng-run Example
Note that you can reuse this logic by creating base class:
@Injectable()
export class BasicHttpClient {
  protected http = createHttpClient(this.injector, [Interceptor2]);
  constructor(private injector: Injector) { }
}
@Injectable({ providedIn: 'root' })
export class TodosApiService extends BaseHttpClient {
  getTodo() {
    // Interceptor2 will be bypassed
    return this.http.get('https://jsonplaceholder.typicode.com/todos')
  }
}
http-client.factory.ts
import {
  HTTP_INTERCEPTORS,
  HttpBackend,
  HttpClient,
  HttpEvent,
  HttpHandler,
  HttpInterceptor,
  HttpRequest,
} from '@angular/common/http';
import { Observable } from 'rxjs';
import { Injector, Type } from '@angular/core';
class HttpInterceptorHandler implements HttpHandler {
  constructor(private next: HttpHandler, private interceptor: HttpInterceptor) {}
  handle(req: HttpRequest<any>): Observable<HttpEvent<any>> {
    return this.interceptor.intercept(req, this.next);
  } 
}
class HttpInterceptingHandler implements HttpHandler {
  private chain: HttpHandler | null = null;
  constructor(
    private backend: HttpBackend,
    private injector: Injector,
    private interceptorsToExclude: Type<HttpInterceptor>[],
    private intercept?: (req: HttpRequest<any>) => HttpRequest<any>
  ) {}
  handle(req: HttpRequest<any>): Observable<HttpEvent<any>> {
    if (this.intercept) {
      req = this.intercept(req);
    }
    if (this.chain === null) {
      const interceptors = this.injector
        .get(HTTP_INTERCEPTORS, [])
        .filter(
          interceptor => !this.interceptorsToExclude.some(interceptorType => interceptor instanceof interceptorType)
        );
      this.chain = interceptors.reduceRight(
        (next, interceptor) => new HttpInterceptorHandler(next, interceptor),
        this.backend
      );
    }
    return this.chain.handle(req);
  }
}
export function createHttpClient(
  injector: Injector,
  excludedInterceptors: Type<HttpInterceptor>[],
  intercept?: (req: HttpRequest<any>) => HttpRequest<any>
) {
  return new HttpClient(
    new HttpInterceptingHandler(injector.get(HttpBackend), injector, excludedInterceptors, intercept)
  );
}