To import modules from a .zip file, you need to add that file to sys.path - then it will act as a search directory. The zipimport module that does the job is a built-in one.
sys.path is constructed like this:
So, you can move all the standard modules into the predefined .zip file. But you may need to leave an os.py or lib-dynload if sys.prefix and sys.exec_prefix become blank after that (the contents are irrelevant, the moved modules will be imported from the .zip because it's earlier on sys.path), or you will lose access to all 3rd-party modules.
Subdirectories that have their own entry in sys.path you need to handle separately so that their contents can still be found on sys.path.
(tested in Python 2.7-win32)
Though adding .pyc files to the archive is sufficient, pdb and stacktraces will be useless unless you place .pys there as well.