I'm not sure how to phrase my search in order to find it so this is probably a duplicate. Please feel free to point me in the right direction.
In pandas, I know that I can use iloc to grab particular pieces of a dataframe.
I'm curious to know if there is a way to Read or Write particular items from said dataframe. 
In one case, I could get item08 by using (1, 1) and then reading it
Or perhaps I want item28 I could use (2, 4)
Maybe I'd like to change item22 on (2, 3) 
  +--------------------------------------------+
0 | item01 | item07 | item13 | item19 | item26 |
  +--------------------------------------------+
1 | item02 | item08 | item14 | item21 | item27 |
  +--------------------------------------------+
2 | item03 | item09 | item15 | item22 | item28 |
  +--------------------------------------------+
3 | ...    | ...    | ...    | ...    | ...    |
  +--------------------------------------------+
      0         1        2        3        4
How can this be done?
 
    