Pluses:
First: mild, defeatable obfuscation.
Second: if compilation results in a significantly smaller file, you will get faster load times. Nice for the web.
Third: Python can skip the compilation step. Faster at intial load. Nice for the CPU and the web.
Fourth: the more you comment, the smaller the .pyc or .pyo file will be in comparison to the source .py file.
Fifth: an end user with only a .pyc or .pyo file in hand is much less likely to present you with a bug they caused by an un-reverted change they forgot to tell you about.
Sixth: if you're aiming at an embedded system, obtaining a smaller size
file to embed may represent a significant plus, and the architecture is stable so drawback one, detailed below, does not come into play.
Top level compilation
It is useful to know that you can compile a top level python source file into a .pyc file this way:
python -m py_compile myscript.py
This removes comments. It leaves docstrings intact. If you'd like to get rid of the docstrings as well (you might want to seriously think about why you're doing that) then compile this way instead...
python -OO -m py_compile myscript.py
...and you'll get a .pyo file instead of a .pyc file; equally distributable in terms of the code's essential functionality, but smaller by the size of the stripped-out docstrings (and less easily understood for subsequent employment if it had decent docstrings in the first place). But see drawback three, below.
Note that python uses the .py file's date, if it is present, to decide whether it should execute the .py file as opposed to the .pyc or .pyo file --- so edit your .py file, and the .pyc or .pyo is obsolete and whatever benefits you gained are lost. You need to recompile it in order to get the .pyc or .pyo benefits back again again, such as they may be.
Drawbacks:
First: There's a "magic cookie" in .pyc and .pyo files that indicates the system architecture that the python file was compiled in. If you distribute one of these files into an environment of a different type, it will break. If you distribute the .pyc or .pyo without the associated .py to recompile or touch so it supersedes the .pyc or .pyo, the end user can't fix it, either.
Second: If docstrings are skipped with the use of the -OO command line option as described above, no one will be able to get at that information, which can make use of the code more difficult (or impossible.)
Third: Python's -OO option also implements some optimizations as per the -O command line option; this may result in changes in operation. Known optimizations are:
sys.flags.optimize = 1
assert statements are skipped
__debug__ = False
Fourth: if you had intentionally made your python script executable with something on the order of #!/usr/bin/python on the first line, this is stripped out in .pyc and .pyo files and that functionality is lost.
Fifth: with option -O, as well as -OO, assert statements are not compiled in, eliminating a source of runtime validation. You can compensate for this by using try except but this requires abandoning the assert statement for use in anything that will be compiled.
Sixth: somewhat obvious, but if you compile your code, not only can its use be impacted, but the potential for others to learn from your work is reduced, often severely.